Purpose:
To study the possible role of dietary glutamate in stimulating the brain to produce abnormally high blood levels of certain hormones.
Research Institution:
University of Pittsburgh School of Medicine, Pittsburgh, PA
Scientist(s):
John D. Fernstrom
Results Published:
"Short-term Neuroendocrine Effects of a Large Oral Dose of Monosodium Glutamate in Fasting Male Subjects," Clinical Endocrinology and Metabolism, 1996.
Study Design:
- Fasting men were given a large (12.7 grams) oral dose of MSG or a high protein meal.
- Subjects were also given both a negative control or positive control to elevate levels of several hormones in order to assess brain function.
- Hormone levels were measured following all administrations.
- Subjective participant feelings were evaluated by self-rating questionnaires.
Study Results:
Plasma levels of hormones evaluated were unaffected by MSG. Even following a high dose of MSG, little or no effect on hypothalamic or pituitary function was observed. The self-evaluation revealed no mood or physical effects were experienced during the two days following treatment.